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28 The environment acts as a triggering factor for ACPA production in RA and the epigenetic regulation combines environment with genes

Resveratrol has a protective effect due to its ability to regulate multiple signaling pathways

Most individuals tolerate MSM exceptionally well, with side effects being rare and typically limited to mild gastrointestinal issues like bloating or nausea

DNA methylation in folate deficiency: use of CpG methylase

doi:10.1111/j.1365-313X.2007.03280.x

Blood Adv 4(13):30003010 Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H (2015) Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial