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Targeted CRISPR-Cas9 screens under compartment-specific GSH limitation To investigate compartment-specific vulnerabilities in cells with uncoupled mitochondrial and cytosolic GSH pools, we performed a metabolism-targeted CRISPR-Cas9 screen in Jurkat cells expressing GshF or mito-GshF in which the recently identified mitochondrial GSH transporter, SLC25A39, was knocked out (Fig

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Dowlatshahi 2013