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PubMed , Scientific Reports , vol

Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al

Maintenance Therapy In some situations, individuals with known B12 deficiency may require ongoing maintenance therapy with methylcobalamin injections to prevent recurrence

88,100,140,141 However, some studies have also found that CHD8 is a positive regulator of the Wnt/-catenin signalling pathway in NPCs and negatively regulates this pathway in nonneuronal cell lines, suggesting that CHD8 may regulate Wnt signalling in a cell-specific manner