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Deuterium-labelled glucose ([1- 2 H]glucose or [3- 2 H]glucose) provides a perspective complementary to carbon tracing by measuring the fraction of NADPH that is produced by the oxPPP, as opposed to by other enzymes such as IDH1, ME1 and aldehyde dehydrogenase 1 family member L1 (ALDH1L1) (refs

2c), further supporting our conclusion that these animals accumulate excessive thiol antioxidants

10.1016/j.ejphar.2018.07.007 117 LopesC.PereiraC.MedeirosR

Lin M-H, Yen J-H, Weng C-Y, Wang L, Ha C-L, Wu M-J (2014) Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways

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