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Cells overexpressing HRASV12 or cyclin E1 accumulate R-loops during S and G2 phases of the cell cycle To investigate the molecular mechanisms underlying R-loop formation induced by overexpression of HRASV12 or cyclin E1, we used a U2OS T-REx cell line conditionally expressing catalytically inactive RNase H1 fused to green fluorescent protein [RNH1(D210N)-GFP] 32