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The present review categorized strategies that promote an increase in NAD + levels into two main approaches: NR, NMN, NA, NRH and NMNH have been identified as precursors of NAD + biosynthesis

Such modifications then activate NF-B that is involved in the expression of proinflammatory mediators such as TNF and IL-6, 343,344 and that induces key steroidogenic molecules, like CYP11A1, CYP17A1 and StAR, leading to further aggravation of hyperandrogenemia

Thus, an improved understanding of the regulation of UA and its neuroprotective action in the human brain will shed further light on neurodegenerative processes and potentially identify novel targets for pharmacotherapeutic intervention

(2021) 73:e17625

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10.1016/j.jare.2019.05.003 213 WuK