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doi: 10.1021/acs.nanolett.4c03418 60 SuJTangLLuoYXuJOuyangS

Acts as antioxidant and detoxifier

Several glycolytic inhibitors, including BAY-876,2-deoxyglucose (2-DG), 3-bromopyruvate (3-BrPA), and plant-derived compounds such as genistein, methyl jasmonate, and shikonin, are under preclinical and early clinical evaluation

Gastroenterology (2017) 152(7):16718

The mean serum selenium concentrations observed in the present study cohort were markedly higher than the recommended concentrations, indicating that the adverse effect of selenium on blood pressure in obese males is associated with selenium overexposure

Collectively, these factors underscore that the bidirectional threshold must be interpreted flexibly rather than as a universal cut-off, highlighting the need for personalized approaches in both research and clinical translation