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Additionally, elevated levels of the plasma amino acid homocysteine can be a functional marker of folate, vitamin B12, or vitamin B6 deficiency, as all these vitamins are required to convert homocysteine into methionine

Too high levels of hydrogen peroxide may lead to saturation of catalase active sites resulting in the inhibition of the enzyme

LiuXTedeschiSKLuBZaccardelliASpeyerCBCostenbaderKHet al

Moreover, these proteins may misfold, further impair proteasomal and autophagic pathways

With progressive understanding of RA pathogenesis, more and more targets for gene therapy will be identified with better specificity

References: Anderson SD, Anderson KV (2023): Drugs for Heart Failure