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diazepam, ethosuximide, lamotrigine, phenytoin) by inhibiting their metabolism or protein binding displacement (7.2) Patients stabilized on rufinamide should begin valproate therapy at a low dose, and titrate to clinically effective dose (7.2) Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote Sprinkle Capsules (7.2) Topiramate: Hyperammonemia and encephalopathy (5.10, 7.3) Use In Specific Populations Pregnancy: Depakote Sprinkle Capsules can cause congenital malformations including neural tube defects and decreased IQ (5.2, 5.3, 8.1) Pediatric: Children under the age of two years are at considerably higher risk of fatal hepatotoxicity (5.1, 8.4) Geriatric: Reduce starting dose

Haidara, Cairo University, Egypt Updates Copyright 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic

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