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Mitochondria are the powerhouse of the cell, continuously providing large amounts of adenosine triphosphate (ATP) to cardiomyocytes which require an extraordinary ATP turnover to maintain contractile function

Science 349 , 650655 (2015)

L-glutamate is also the precursor of glutathione (L--glutamyl-L-cysteinylglycine, GSH)

"'Connecticut' could use more of Arnold's muscle"

Furthermore, the apoptosis of SGNs detected by C-CASP3 immunostaining and western blot showed that there was much less C-CASP3-positive SGNs and remarkable reduction of the C-CASP3 protein levels in the NAC co-treated groups compared with the peroxynitrite-only groups, and it was also lower in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figures 7B,C)

Recent studies with long-acting bronchodilators have demonstrated the positive impact of lung deflation on cardiac function in COPD patients with static hyperinflation [15, 29,30,31,32]