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doi:10.1016/S0026-0495(96)90171-7

It is studied for its selective action on lipolytic pathways without activating the IGF-1 receptor

Mechanism review Wan and colleagues (2023, Journal of Translational Medicine ) and Kong and colleagues (2023, Diabetes & Metabolism Journal ) reviewed AMPK activation, mitochondria-to-nucleus signaling, and the link between MOTS-c and aging-related metabolic disease

doi: 10.1016/j.expneurol.2014.04.008

Clinical applications might include both acute ligament injuries and chronic ligamentous laxity or instability, though human efficacy data is needed to validate these potential indications