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347,348 Aging-related NAD + decline causes mitochondrial dysfunction Combining the evidence that mitochondrial dysfunction is a hallmark of aging and NAD + plays a crucial role in the maintenance of mitochondrial function

The innate immune response is a first step to protecting against pathogens, which stimulate the interferon signaling pathway and expression of IFN-I, leading to an antiviral cellular response [51]

Side effects and safety considerations Most side effects are mild

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A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice