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Transferrin saturation/hepcidin ratio discriminates TMPRSS6-related iron refractory iron deficiency anemia from patients with multi-causal iron deficiency anemia

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For instance, NCOA4-mediated ferritinophagy may impact the activity of glutathione peroxidase 4 (GPX4), as increased iron levels can deplete intracellular antioxidants like glutathione, indirectly inhibiting GPX4 function and thereby facilitating ferroptosis (Mancias et al., 2014)

1 Introduction The world population has increased by 14% in the past 12 years, reaching the 8.0-billion milestone in 2022, and is expected to continue, peaking at 9.7 billion in 2050 and 10.9 billion in 2100 ( Plant cell culture (PCC) technology for commercial use has been deployed since the 1980s to produce pharmaceuticals, cosmetics, and, most recently, food ingredients ( Currently, two plant cell lines, scurvy grass (SG, Cochlearia danica , Brassicaceae) and rowan (RW, Sorbus aucuparia , Rosaceae), are being developed as potential novel food ingredients for commercialization at an industrial scale

Furthermore, the depletion of GSH in mice led to increased susceptibility to melioidosis, reduced production of IL-12p70, and poorer disease outcome

Commonly Reported Effects Injection site reactions represent the most frequent complaint, typically involving mild redness, itching, or temporary discomfort at the injection location