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These cytokines may individually or synergistically stimulate CRH secretion, ultimately leading to increased glucocorticoid release, appetite suppression, and exacerbation of muscle wasting in patients

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pmid:7614519

doi: 10.1038/s41574-020-00414-9 211 ChengFXiaoJShaoCHuangFWangLJuYet al

Dokmeci, D., Inan, M., Basaran, U