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For use by qualified researchers in appropriate laboratory settings only

A total of 521 pre/postmenopausal women were randomized 2:1 to IBRANCE plus fulvestrant or placebo plus fulvestrant and stratified by documented sensitivity to prior hormonal therapy, menopausal status at study entry (pre/peri versus postmenopausal), and presence of visceral metastases

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If an adverse reaction is observed during administration, the infusion should be stopped immediately , the patient evaluated and treated as needed, and the remaining solution saved for analysis if contamination is suspected ( Sterile Water Injection Dosage and Administration Using Sterile Water for Reconstitution: The volume of sterile water needed to dilute a medication depends on the specific drugs requirements typically outlined in the drugs package insert

In two investigations on ovarian carcinoma cells, Alonezi et al