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In this context, it is still debated whether inflammation directly causes neurodegeneration or the neuronal loss induces glia activation, generating a positive feedback loop in which inflammatory cytokines and neurotoxic molecules released by activated glial cells promote both neurodegeneration and self-perpetuating inflammatory response (Figure 1B)

The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens

Unlike in humans, LCA is normally only minimally present in rodents 77 , and exogenous LCA feeding can have serious detrimental consequences for mice, including hepatobiliary injury leading to eventual death 78

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Curiously, the BP moiety appears to adopt multiple conformations in our 10 S ()- cis -BP-dG ternary complex structure

The questionnaire consists of 29 items categorized into 6 domains, each item scored 1-7, with an overall HRQoL score, which is a summation of scores of all items