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The presence of Au-NPs in the gold nano-extract, known for its anti-inflammatory properties, normalized mRNA levels of inflammation markers and antioxidant enzymes, modulating the biological response at a molecular level by reducing inflammatory gene expression and increasing antioxidant gene expression 116

J Clin Endocrinol Metab 98(3):10311039

Still, this does not preclude extramitochondrial CHAC1 from concurrently influencing ferroptosis, as we show that CHAC1 loss significantly spares cytosolic GSH under cystine starvation, a significant factor in the capacity of cells to mitigate lipid peroxidation 11

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Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, and surgical methods