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Estrogen signaling, via GPER1 activation, mitigates inflammation and remodeling, while ER and ER inhibition limits proliferation and ECM remodeling

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Vitamin B12 deficiency thus leads to the poor regeneration of and gradual damage to the myelin sheaths (29)

The treatment of allergic disease is a good example of this approach, where integrative and holistic medicine involves not merely suppressing the troublesome symptoms (for example, itchy skin), but tries to determine the underlying immune imbalances that lead to the allergic symptoms

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