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10.3390/ijms23073633 173 ShabbirU.AnjumI.Naveed MushtaqM.Nasir Hayat MalikM.IsmailS.JavedJ.et al (2022)

While initially beneficial, adaptive hyperfiltration can lead to further injury and long-term decline in kidney function

GSK3, a serine-threonine kinase prominently expressed in the brain, augments the activity of -secretase while concurrently diminishing the activity of -secretases, thereby amplifying intra- and extracellular levels of A [59, 60]