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We believe severability applies to each provision of the Part D inflation drug rebate regulation, because deeming any particular provision to be invalid or illegal would not result in a material change to the Medicare Part D Inflation Rebate Program so as to cause all of the requirements that compose the program to be invalid

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Although such immune imprinting appears to be beneficial for induction of broadly reactive antibodies against known variants, it hinders induction of neutralizing responses against novel epitopes