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Transporter-Mediated Nanocarrier Delivery Approach The transporter-mediated nanocarrier delivery strategy is based on the incorporation of transporter substrates on the nanocarrier surface, which bind to the transporter protein on the cellular membrane and trigger the internalization process (80)

doi: 10.1152/ajplung.00132.2009 189 RempeK

However, its effects on BBB repair after IS are not completely understood

Patel PA, Patil SC, Kalaria DR, Kalia YN, Patravale VB (2013) Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A

doi: 10.1016/j.freeradbiomed.2021.05.018 177 LinsenmeierRAZhangHF

The transport kinetic parameters, such as affinity (K m ) and transport capacity (V max ), are essential for understanding the capability of the (pro)drugs to utilize the transporter and planning pharmacokinetics studies