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Bemmaor, J

Pharmacokinetics, Biodistribution, Immunogenicity, and Model-Informed-Based PK/PD Model of a Next-Generation Advanced Novel Gene Therapy for Hemophilia

2023;19:e1010624

Life 14(2):244

3 If the product of a Phase I reaction is not soluble enough to be excreted, a Phase II conjugation reaction will typically accomplish this

While eNOS activation at optimal levels of BH 4 leads to production of NO, activation of NOS in the absence of or in the presence of decreased levels of BH 4 results in generation of superoxide rather than NO in the vascular endothelium