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138 Simultaneously, SIRT3 can not only induce the expression of antioxidant enzymes by activating the FOXO3a, but also enhance the activation of SOD2 and catalase via NAD + -dependent deacetylation

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This means that they each boost the effectiveness, lifespan, and power of each other within the body

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Accordingly, the antioxidant defense system is found to be most useful for treating various neurological disorders

Moreover, statins would reduce the activity of CETP and PLTP, both involved in HDL metabolism and maturation (de Haan et al., 2008