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Zinc signaling is essential for NETosis, as zinc chelation by TPEN inhibits this process without affecting PKC activity or ROS production, suggesting zinc acts downstream of ROS [161]

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2.3 Treatment Outcomes For those who initiate treatment, patients with TB and AUD have worse clinical outcomes, including increased time to culture conversion, incidence of TB treatment failure, rate of disease relapse, and risk of death (25, 28, 3843)

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