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The International Diabetes Federation estimates that 425 million people worldwide have diabetes 1 , making it the largest global epidemic of the 21st century 2

As a naturally occurring tripeptide complexed with copper ions, GHK-Cu serves as an important compound in peptide-based biochemical research

Madrigal et al

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The lid loops also undergo significant conformational changes resulting in Tyr182 inserting into the active site pockets

AGEs promote oxidative stress by generating free radicals through interactions with transition metals such as iron and copper and by impairing antioxidant enzyme systems, thereby diminishing the cellular ability to eliminate ROS (Wei et al., 2013)