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Any of these on their own might not mean much, but several together are worth getting checked

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Avoid using vials past their expiration date, and inspect them for any changes in color or damage

This reaction is catalyzed by an enzyme called histidine decarboxylase, which removes a carboxyl group from histidine, converting it into histamine

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Other symptoms to note : Drug rashes can be a side effect of or a reaction to a new medication