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PanDDA Inspect was used to sequentially assess each event in Coot 35 , and ligands were added to the TRF1 TRFH model if density could be confidently assigned in real space

186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria

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The FSC results in the low scanning rate range agree well with the DSC results and the literature data

Age impairs this process causing lipofuscin accumulation in RPE

Telomerase activation is common in cancer, while excessively short telomeres can also be harmful