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Ursodeoxycholic acid (UDCA, Ursodiol, Urso , Actigall ) has been used for the treatment of several pathological conditions, such as gallstones and PBC

For GSTM1 and GSTT1 status with only two possible genotypes, the odds ratio was compared between cases and controls by the Mantel-Haenszel method

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

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In addition, ethanol inhibits the activity of the endogenous antioxidant system, further weakening the livers ability to scavenge oxidants and increasing hepatocyte susceptibility to oxidative stress (Wu and Cederbaum, 2009)