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In these cases, conventional oral creatine monotherapy is largely ineffective due to impaired transport across the bloodbrain barrier, prompting the exploration of alternative delivery methods such as intranasal supplementation and gene-based therapies [78, 79]

10.1186/s12943-025-02457-w 13 DongM.WangL.HuN.RaoY.WangZ.ZhangY

10.1371/journal.pone.0036055 PLoS One 30 GaoH.BaiY.JiaY.ZhaoY.KangR.TangD.et al (2018)

Guilley H, Dudley RK, Jonard G, Balazs E, Richards KE: Transcription of Cauliflower mosaic virus DNA: detection of promoter sequences, and characterization of transcripts

doi: 10.1186/s13223-018-0278-1 3 PradeuTThommaBGirardinSELemaitreB

MDA, SOD, and GSH-PX The concentration of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) in the blood were determined using MDA, SOD, and GSH-PX assay kits (Beyotime, China), respectively, following the manufacturers instructions