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Primary cortical neurons were maintained in Neurobasal medium (Life Technologies Corporation) supplemented with 1x B-27 (life technology)

It is known that high doses of APAP are toxic for two reasons

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The best explanation is that xenobiotics hit the gland directly via the arterial route, whereas ingested toxicants first encounter the liver which is best equipped to deal with RXS, via its huge complement of GSH and GST (21, 170)

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To explore the molecular basis for these potential changes, we cross-referenced 1178 upregulated DEGs from Dmp1-Cre