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Delgadillo LF, Lomakina EB, Kuebel J, Waugh RE

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Subject terms: Oxidoreductases, Assay systems, Biochemical assays Fusion proteins between roGFP2 and glutaredoxins are used for intracellular redox measurements

The Phase 2b OPTIONS trial 536 obese subjects, randomized to receive 0.25, 0.5, or 1 mg/day oral AOD-9604 or placebo over 24 weeks failed to demonstrate statistically significant weight loss at any dose tested