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Res Sq BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells

S., Pensak, M

Collectively, these strategies demonstrate that metabolically targeting TAM subsets is a powerful approach to controlling ferroptosis, suggesting multiple avenues for combination therapies that integrate ferroptosis inducers, immune checkpoint modulators, and metabolic inhibitors

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We observed that several lipid peroxidation-related markers were inhibited (Fig

This has the potential to synergistically enhance muscle protein synthesis and anabolic signaling based on in vitro evidence