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For topical or in vivo investigational use, concentrations of 0.05% to 0.1% (w/v) have been employed in wound-healing studies without reported adverse events

The Lancet 2013;382:339-52

100 Consistent with this, paracellular flux of [ 3 H]mannitol (hydrodynamic radius of 3.6 ), but not [ 14 C]inulin (hydrodynamic radius of 11.5 ), was also increased, indicating that a decrease in TER resulted from tight junction-dependent permeability, not epithelial damage

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All the patients had findings negative for influenza virus, coxsackie virus, SARS-CoV-2, and parvovirus B19