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Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, et al

Studies show that 60-80% of the population has spider veins, and women are slightly more predisposed to having them

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When to pause dose escalation If you are experiencing significant GI side effects at your current dose, do not increase to the next dose on schedule

In a phase I/II trial that did not identify biomarkers, five out of 25 patients achieved an overall response rate, and the study failed to proceed to the next stage

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