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Air quality differs considerably worldwide, and in many parts of the globe, the adverse health effects of poor air quality are comparable to smoking hundreds of cigarettes a year

PMID 24570145

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Consequently, increased intracellular ROS cause defective angiogenesis, activation of proinflammatory pathways and chronic epigenetic changes which persistently stimulate a pro-inflammatory state even after achieving normoglycemia (hyperglycemic memory) [18]

However, this law was not enforced until 1988