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Niimura et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, 2007

The alpha factor secretion signal present in the vector facilitates the secretion of the expressed fusion peptide into the medium, simplifying purification and potential therapeutic applications

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Mild nausea has also been reported in subjects who are administered doses in excess of 1mg