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In a retrospective analysis of ninety-day toxicity study data from eighty-three mouse studies and eighty-seven rat studies that were also tested for carcinogenicity, the combined presence of hepatocellular necrosis, hepatocellular hypertrophy, hepatocellular cytomegaly, bile duct hyperplasia, and hepatocellular degeneration, along with increased liver weight, was significantly predictive of hepatocarcinogenicity in the two-year study (Allen et al

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doi: 10.1038/s41581023-006833 151 WenYParikhCR

The effect of ALA on this secondary progressive multiple sclerosis was studied in a randomized, double-blind, placebo-controlled phase II clinical trial [130]