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TLRs can be localized either on the cell surface (TLR-1, -2, -4, -5, -6, -10) or in the endosome compartment (TLR-3, -7, -8, -9

J Appl Physiol 106:98895

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doi: 10.1007/s00018-019-03011-w 25 Sanchez-RodriguezE.Egea-ZorrillaA.Plaza-DazJ.Aragn-VelaJ.Muoz-QuezadaS.Tercedor-SnchezL.et al

The structural change ( Figure 7E ) could potentially hinder the transamination reaction, because the loop movement might bring the -amino group of PMP into closer proximity to other amino-acid side groups, such as His192, promoting the hydrogen bond formation that may influence the reactivity of PMP with GSA