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the secondary outcome variables include the serum concentration of vitamin B12 (in pg/ml), adherence to treatment, quality of life (EuroQoL-5D questionnaire), patient 3satisfaction and patient preferences

CD38 is also involved in gliomas where it supports the activation of tumor microglia and macrophages and subsequent tumor progression [55]

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To reduce potential bias, participants were asked weekly whether they had changed their physical activity levels or habitual dietary patterns during the intervention period

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