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However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead

Eychenne, R., Bouvry, C., Bourgeois, M., Loyer, P., Benoist, E., & Lepareur, N

The authors CS, AB, and SI declared that they were an editorial board member of Frontiers at the time of submission