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Despite the treatment with vitamin B12 injections, the patient showed an initial poor response with worsening thrombocytopenia with platelet counts as low as 18K/mm 3

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While each peptide influences distinct biological pathways, together they provide researchers with a comprehensive model for investigating connective tissue remodeling, angiogenic signaling, cytoskeletal organization, and the coordinated cellular processes that maintain tissue homeostasis

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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies