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Funding: This work was supported, in part, by National Institutes of Health ( grants R01 DK058185, P01 DK068055 (Project 2), P30 DK084567, P30 CA015083, P50 CA127003, as well as by the GIST Cancer Research Fund ( and the Mayo Clinic Center for Individualized Medicine The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

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