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In the healthy brain, astrocytes contribute to tonic inhibition by synthesizing and releasing GABA through nonsynaptic mechanisms

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs

Raucy JL, Carpenter SJ, Trzaskos JM

each R is independently hydrogen or-CH 2 CH 2 C(O)OR B Each R B Independently is C 10-14 Alkyl radical, wherein R B Optionally substituted with one or more fluoro groups