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Although previous studies have extensively documented the regulatory function of abnormal lactate metabolism in different cancers, the abnormal metabolism of amino acids in tumors, particularly branched chain amino acids (BCAA), remains a promising avenue that needs further in-depth investigation in future research

73 The activity of GPx is also reduced in diabetes due to a decrease in the availability of its cofactor, selenium

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Because oridonin dramatically increased apoptotic cell and decreased cell viability, it remarkably amplified the anti-tumor impact of cisplatin

Herbal products and the liver: a review of adverse effects and mechanisms

Among these factors, enzyme mutations are the primary drivers of aberrant product formation, while the other conditions often act indirectly by altering enzyme conformation and promoting deviant catalytic routes