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In vitro assays using BaF-BO3 cells transfected with the hGH receptor confirmed that AOD9604 does not compete for the hGH receptor and does not induce cell proliferation unlike intact hGH establishing that it operates via a novel mechanism distinct from traditional hGH-stimulated pathways

At meetings scheduled for July 23 and 24 at the FDAs White Oak Campus in Silver Spring, Maryland, the FDAs Pharmacy Compounding Advisory Committee will consider whether to recommend adding seven peptide substances to the agencys 503A Bulks List, which would allow them to be used in certain compounded prescription drugs

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At the same time, limitations remain obvious: clinical data are still insufficient, most conclusions are based on experimental models, and questions of long-term safety, application protocols, and effectiveness at later stages of degeneration require additional research