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doi: 10.3760/cma.j.cn311847-20191018-00271 34

During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

For example, platinum (IV) prodrugs activated by intracellular GSH have demonstrated enhanced tumor selectivity and reduced systemic toxicity in clinical trials

Semax is an ACTH(4-10) analog (pituitary-derived) studied primarily for nootropic/neuroprotective effects

The number of human peripheral blood CD4 + CD25 high regulatory T cells increases with age

Thompson, D.H