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The reciprocal experiment to specifically cleave K29 linkages was technically challenging at this stage because K29/K33-linkage-specific TRABID can also cleave other linkages such as K63 linkage in vitro 34

Abbreviations: APCs antigen-presenting cells AuNSs Au nanoshells BBB bloodbrain barrier BBTB bloodbrain tumor barrier CTCs circulating tumor cells CXCR3 CXC chemokine receptor 3 CXCR4 CXC chemokine receptor 4 cRGD cyclic arginineglycineaspartate DC-MVs DC membrane vesicles DCs dendritic cells DOX doxorubicin EPR enhanced permeation and retention EVs extracellular vesicles HIFU focused ultrasound GSH glutathione MHC histocompatibility complex LINVs hybrid nanovesicles after fusion HCQ Hydroxychloroquine HIF hypoxia-inducible factor ICD immunogenic cell death iDCs intelligent nano-DCs LIPs liposomes MSCMs mesenchymal cell membranes MSCs Mesenchymal stem cells MPS mononuclear phagocyte system NPs Nanoparticles NK cells natural killer cells Nes neutrophils OMVs outer membrane vesicles PI3K/AKT phosphatidylinositol-3-kinase/protein kinase B PDT Photodynamic therapy PSs photosensitizers PDGF platelet-derived growth factor PDI polydispersity index PEG polyethylene glycol P-sel P-selectin FeS 2 pyrite ROS reactive oxygen species RBCs Red blood cells Sirp signal-regulated protein SDSPAGE Sodium dodecyl sulfatepolyacrylamide gel electrophoresis SDF1 stromal cell-derived factor-1 TCR T-cell receptor TEM transmission electron microscopy TME tumor microenvironment TAAs tumor-associated antigens TNVs tumor-derived nanovesicles Data availability No data was used for the research described in the article

Studies also show that tirzepatide may increase the risk of gallbladder disease

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