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In anti-inflammatory and anti-fibrotic approaches, novel nonsteroidal mineralocorticoid receptor antagonists such as finerenone inhibit the TGF-/Smad3 pathway, alleviating renal interstitial inflammation and collagen deposition ( Multi-target traditional Chinese medicine interventions also demonstrate promise, such as Huangkui capsule (containing quercetin and kaempferol as primary active components), which regulates the PI3K/Akt and AGE-RAGE signaling pathways while improving insulin resistance, inhibiting lipid accumulation, and suppressing NF-B-mediated inflammation (Niu et al., 2022

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EPS of Lactobacillus species engage with TLR2, stimulating the PI3K/Akt/mTOR pathway to enhance IFN- production and restore NK cell cytotoxicity suppressed in SLE ( Figure 2 ) (113)

BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia