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Results Differential Autoimmune Responses in Lupus-Resistant/-Prone Mice MRL+/+ mice spontaneously but very slowly develop autoantibodies several months after birth and lupus-like glomerulonephritis (SLE) late in the second year of life ( Figures 1A, B , ANA and ASMA levels were very low at 6 weeks of age in both MRL+/+ and MRL/lpr mice, but significantly increased in MRL/lpr mice at 18 weeks compared to other two strains