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The plasma concentration of VEGF in cancer patients rises as the disease progresses, indicating that the tumor tissue is the primary source of VEGF [3]

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10.1038/S41586-024-07472-3 41 ToyodaY.ChangM

Each subtype has unique clinical outcomes, phenotypes, and therapeutic sensitivities, which guide treatment decisions and influence prognosis

Hence, nanoparticle vector-mediated gene editing delivery systems has been developed for specific gene targeting in disease therapy which include lipid nanoparticles [92], polymeric nanoparticles [93], gold nanorods [94, 95], SPIONs [18], solid lipid nanoparticles [18] and exosome-based carriers [96]